Epcam role in cancer and Anti-epcam drugs

A fusion protein immunotoxin consisting of a humanized, single-chain monoclonal antibody fragment specific for the epithelial cell adhesion molecule (EpCAM) conjugated with a truncated form of Pseudomonas exotoxin A with potential antineoplastic activity. Anti-EpCAM-Pseudomonas-exotoxin fusion protein binds to Ep-CAM-positive tumor cells, thereby delivering the Pseudomonas exotoxin A moiety specifically; the Pseudomonas exotoxin A moiety then inactivates elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein synthesis in target cells. EpCAM, a cell surface protein, is expressed by a variety of tumor cells and is frequently found in head and neck cancers. Check for active clinical trials or closed clinical trials using this agent.
http://www.cancer.gov/drugdictionary/?CdrID=485164

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http://pis.to/cgtg/publications/Kanerva%20Hemminki.%20Int%20J%20Cancer%20Review%2004.pdf

http://clincancerres.aacrjournals.org/content/13/13/3899.full

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