After a break, reading through this text: http://emitak.blogspot.com/2009/05/blog-post_06.html#comment-form, my mind was clearer and now the difference between the dif. types of phase 2 metabolism are crystal clear!
One of the first things that M.M. told us was that Glucuronidation is not the same metabolic process as that performed by β-D-glucuronidase. Glucuronidation is all about UDP leaving the sugar and allowing the nucleophilic xenobiotic (drug) to bind to the sugar, changing the stereochemistry from α to β. Now, the role of β-D-glucuronidase is that if after glucuronidation the drug is not hydrophilic enough to be excreted in the urine, then it is recycled by passing to the bile. β-D-glucuronidase cleaves the drug and glucuronide apart, recycling the drug and increasing its hald-life.
In case a drug is toxic, glutathione is going to be used to remove the toxic electrophile. This happens in the case of paracetamol.
One of the first things that M.M. told us was that Glucuronidation is not the same metabolic process as that performed by β-D-glucuronidase. Glucuronidation is all about UDP leaving the sugar and allowing the nucleophilic xenobiotic (drug) to bind to the sugar, changing the stereochemistry from α to β. Now, the role of β-D-glucuronidase is that if after glucuronidation the drug is not hydrophilic enough to be excreted in the urine, then it is recycled by passing to the bile. β-D-glucuronidase cleaves the drug and glucuronide apart, recycling the drug and increasing its hald-life.
In case a drug is toxic, glutathione is going to be used to remove the toxic electrophile. This happens in the case of paracetamol.
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