Dangers of recreating and giving to human drugs only tested on rats

Drugs tested only on rats in laboratories are recreated for human use. These drugs are not yet defined as illegal, hence they are made up. However, they mighthave severe side effects to humans and they might even be fatal.
http://blogs.discovermagazine.com/80beats/2011/01/05/drug-users-are-mining-the-scientific-literature-for-legal-highs/