MYTH: CAN NITROGLYCERIN HEART PATCHES, WORN BY PATIENTS WITH ANGINA, EVER EXPLODE?

http://dsc.discovery.com/fansites/mythbusters/db/technology/nitroglycerine-heart-patches-explode.html

Epigenetics

I came across the term epigenetics during Roche-Continents Workshops.
This is a link with information of what it is:
http://learn.genetics.utah.edu/content/epigenetics/
http://learn.genetics.utah.edu/content/epigenetics/inheritance/

GABA-A receptor

http://www.google.com/imgres?imgurl=http://media.wiley.com/CurrentProtocols/NS/ns0706/ns0706-fig-0001-1-full.gif&imgrefurl=http://www.currentprotocols.com/protocol/ns0706&usg=__Rv4x2ttXFQH_rVZ0t6P0ZifMMFw=&h=255&w=363&sz=5&hl=el&start=39&zoom=1&tbnid=udPgYmqRsn2AXM:&tbnh=140&tbnw=200&prev=/images%3Fq%3Ddiazepam%2Bbinding%2Bsite%26um%3D1%26hl%3Del%26rls%3Dcom.microsoft:el:IE-SearchBox%26rlz%3D1I7GGLL_el%26biw%3D1259%26bih%3D573%26tbs%3Disch:10%2C942&um=1&itbs=1&iact=hc&vpx=900&vpy=225&dur=5553&hovh=188&hovw=268&tx=103&ty=111&ei=Ip6MTJGUDs2Vswaq5PG1Ag&oei=GJ6MTPSoFoaBswbUlPDlAQ&esq=3&page=3&ndsp=20&ved=1t:429,r:12,s:39&biw=1259&bih=573


http://www.currentprotocols.com/protocol/ns0706

Porphyria

I was reading about the skeletal muscle relaxants and I came across with the term porphyria.
According to BNF54 acute porphyria is a hereditary disorder of haem biosynthesis. Subdivisions include: Acute intermittent porphyria (AIP), Variegate porphyria (VP), Hereditary coproporphyria (HCP), or ALA dehydratase deficiency porphyria.

There are drugs can cause acute porphyrias and their use must be avoided. If that is not possible urinary porphobilinogen excretion should be measured regularly.

A list of drugs safe to use in acute porphyrias can be found here:
http://www.wmic.wales.nhs.uk/pdfs/porphyria/Porphyria_Safe_List_2010_with_letter_August%202010.pdf

In acute porphyria crises, haema arginate (normosang) is given as an IV infusion.

More information can be found here:
http://www.wmic.wales.nhs.uk/porphyria_info.php

http://www.porphyria-europe.com/01-for-patients/EN/for-patients.asp

Angelman syndrome

http://www.angelman.org/

http://ghr.nlm.nih.gov/condition/angelman-syndrome

http://en.wikipedia.org/wiki/Angelman_Syndrome

Antispasticity Drugs

http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=spinalcord&part=A3650&rendertype=figure&id=A3651

http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=spinalcord&part=A3650

Tetanus

Tetanus is an serious, acute infection caused by the bacterium Clostridium tetani, which is found in the soil, dust and manure. The bacterium usually enters the skin through grazes, wounds and burns.
After entering the body, it needs up to 21 days to incubate and usually symptoms appear after the 10 days. Symptoms include muscle spasm which is particularly apparent on the face, fever, sweating, tachycardia and hypertension. If it is not treated it can lead to fatal complications which include septicaemia, asphyxia, heart attack and kideny failure.
To prevent infection wound must be cleaned and antiseptics must be used or if severe the wound should be treated appropriately by a healthcare professional. Vaccination might also need to follow.
Antibiotics may also be given to limit the bacteria growth and the neurotoxin tetanospasmin spreading. Penicillin or metronidazole are usually given and tetracycline is given to those allergic to the aforementioned antibiotics.
Muscle spasms are treated by anticonvulsants (phenobarbital), muscle relaxants (diazepam, baclofen, dantrolene) and neuromuscular blocking agents (vecuronium).
A high calorie and protein-rich diet might be also necessary due to increased muscle activity and energy consumption.

http://www.nhs.uk/Conditions/Tetanus/Pages/Introduction.aspx